It occurred to me today while thinking about it, that the genesis of the Orsimer is strangely tied to the Chimer's war against the Dwemer. According to lore, Trinimac lead his people in war against the Chimer, who sought the technology of the Dwemer, and was subsequently devoured by Boethiah, twisting him into Malacath and transforming his followers into the Orsimer. However, Malacath himself says that this is not a literal recounting of what occurred - we can only assume it has some symbolic meaning relating to the reality of their genesis. Further, the Orsimer originated in Hammerfell, the centre of the Dwemer's power and the site of their transformation (they moved north after the arrival of the Redguards).
The orsimer are by no means a stupid race. Their armor and weapons are among the finest in Tamriel; that kind of smithing talent seems incredibly unlikely to have originated from their constant forced nomadism and barbarian culture. It seems more like the remnants of a deeper knowledge lost and carried on through traditional practice.
I'd like to know what you guys think. Is it possible that the Dwemer did something in the course of their war that twisted them into their current form? It seems a possible explanation for the sudden disappearance of an entire people, and the unexpected emergence of the Orsimer.