...Any ideas would be appreciated...
A reliable healing skill is
very useful in FCOM... if you only use alchemy you'll need some good apparatus and your healing potions on hotkey.
My experience with using Blade/Marksmanship/Sneak is that there will be many situations where enemies will close fast and in significant numbers without much room for maneuver... so the option is to run, use some sort of invisibility, or engage in melee.
I ended up with a blade skill roughly twice that of of marksmanship- if using a leveling system similar to that of vanilla, sneak kills with a bow yield little experience because they tend to kill quickly with few shots... good for taking out the first foe but can get a little boring if your a sneak master and take out all foes from the shadows (applies to sneaking with blade as well). So I ended up using my blade very often in general and my bow for easy sneak-kills and for taking out large, dangerous, high hit point, creatures in the open.
I don't think armor choice will make much difference in the end, depending on what mods you use. Unless your set on Alchemy as a major (maybe for role-play), I would suggest a magic skill, maybe Illusion or Restoration instead... both will come in handy.
Otherwise, you have the right idea with choosing majors that your actually going to be using.
Edit: Tip: a bow enchanted with the Burden effect is one of my favorite weapons... even better if using Supreme Magicka.