So I'm starting a new playthrough after a fresh install and I'm having infinite loadscreens 9 out of 10 times I either load a save or travel between areas. Can any of you see what the issue might be from my load order? Thanks so much!

00  Skyrim.esm01  Update.esm02  Dawnguard.esm03  HearthFires.esm04  Dragonborn.esm05  Falskaar.esm06  RaceCompatibility.esm07  ClimatesOfTamriel.esm08  SPIKE.esm09  XFLMain.esm0A  HighResTexturePack01.esp0B  HighResTexturePack02.esp0C  HighResTexturePack03.esp0D  Brawl Bugs CE.esp0E  Unofficial Skyrim Patch.esp  [Version 1.3.3c]0F  RaceCompatibilityUSKPOverride.esp10  Unofficial Dawnguard Patch.esp  [Version 1.2.4]11  Unofficial Hearthfire Patch.esp  [Version 1.1.2]12  Unofficial Dragonborn Patch.esp  [Version 1.0.5]13  Unofficial High Resolution Patch.esp  [Version 1.1.2]14  Serana.esp15  Chesko_Frostfall.esp16  Morning Fogs.esp17  SplashofRain.esp18  Supreme Fog - CoT.esp19  Immersive Sounds - Magic.esp1A  StaticMeshImprovementMod.esp1B  StaticMeshImprovementMod-DragonbornTernFix.esp1C  StaticMeshImprovementMod-FurnitureChestSnowFix.esp1D  83Willows_101BUGS_V4_HighRes.esp1E  Birdsofskyrim.esp1F  Chesko_WearableLantern.esp20  Chesko_WearableLantern_Guards.esp21  Chesko_WearableLantern_Caravaner.esp22  falskaar_loadscreen_fix.esp23  Loadscreens Extended.esp24  NS_HuntingGroundsOutfit.esp25  Book Covers Skyrim.esp26  Book Covers Dawnguard.esp27  Book Covers Hearthfire.esp28  Book Covers Dragonborn.esp29  RealShelter.esp2A  Real Clouds.esp2B  Skyrim Immersive Creatures.esp  [Version v6.1.2]2C  Skyrim Immersive Creatures - DLC2.esp  [Version v6.1.2]2D  Skyrim Flora Overhaul.esp2E  Smoking Torches.esp2F  SPTDiverseGuardsSkyrim.esp  [Version 4.5]30  TouringCarriages.esp31  DYNAVISION Dynamic Depth of Field.esp32  Footprints.esp33  Footprints - Ash.esp34  UIExtensions.esp35  WetandCold.esp36  WetandCold - Ashes.esp37  SkyUI.esp38  iHUD.esp39  Cloaks.esp3A  Cloaks - Dawnguard.esp3B  1nivWICCloaks.esp  [Version 2.3]3C  1nivWICSkyCloaksPatch.esp  [Version 2.3]3D  hothtrooper44_ArmorCompilation.esp3E  Immersive Weapons.esp3F  Unique Uniques.esp  [Version 1.5]40  zz_GDRAHoods.esp41  zzMaidOutfits.esp42  Dr_Bandolier.esp43  Dr_BandolierDG.esp44  BandolierForNPCMasterFile.esp  [Version 4.0]45  BandolierForNPCsWIC_V2.esp46  BandolierForNPCsCheaperBandoliers_BalancedWeight_Dawnguard.esp47  Requiem.esp48  Requiem - Resources.esp49  Requiem - Falskaar.esp4A  Requiem - Immersive Weapons.esp4B  Requiem - Dragonborn.esp4C  Requiem - HearthFires.esp4D  Requiem - SIC Patch - DLC2.esp4E  Requiem - Immersive Armors.esp4F  AgentOfRighteousMight.esp50  BetterRiften.esp51  CollegeOfWinterholdImmersive.esp52  RIC_Dawnstar.esp53  Hebrock_Der Spvssyn von Meresis - EV.esp54  Inconsequential NPCs.esp55  Inconsequential NPCs - Enhancement.esp56  Markarth_plus.esp57  MzarkWonders.esp58  Realcitiessolitude.esp59  RiverWood Redux.esp5A  Riverwood Redux Expanded Basemant.esp5B  DawnofWindhelm.esp5C  Morthal walls.esp5D  The Paarthurnax Dilemma.esp  [Version 1.2.5]5E  Wyrmstooth.esp  [Version 1.9]5F  AchieveThat.esp60  Babette.esp61  FalskaarDawnguard.esp62  Headtracking.esp63  SFO - Expanded Diversity.esp64  Unique Grasses.esp65  dD - Enhanced Blood Main.esp66  dD-Dragonborn-Dawnguard-EBT Patch.esp67  TheChoiceIsYours.esp68  TheChoiceIsYours_Dawnguard.esp69  Helgen Reborn.esp  [Version 104]6A  WhiterunAlivePiano.esp6B  SoS - The Dungeons.esp  [Version 1.23]6C  SoS - The Wilds.esp  [Version 1.13]6D  SoS - Civilization.esp  [Version 1.02]6E  ClimatesOfTamriel-Sound.esp6F  EnhancedLightsandFX.esp70  ELFX - Exteriors.esp71  ELFX - Dawnguard.esp72  ClimatesOfTamriel-Dawnguard-Patch.esp73  ClimatesOfTamriel-Dragonborn-Patch.esp74  ClimatesOfTamriel-Dungeons-hardcoe.esp75  ClimatesOfTamriel-Interiors-Warm.esp76  ClimatesOfTamriel-Nights-Level-8.esp77  SoS - The Dungeons-PatchCoThardcoe.esp78  SoS - The Wilds-PatchCoTSounds.esp79  SoS - Civilization -PatchCoTSounds.esp7A  DragonCombatOverhaulDragonborn.esp7B  vImmersiveBeds.esp7C  vImmersiveBeds - HFDG.esp7D  TheEyesOfBeauty.esp  [Version 8]7E  The Ningheim.esp7F  3DNPC.esp80  RealisticNeedsandDiseases.esp81  RND_Dawnguard-Patch.esp82  RND_HearthFires-Patch.esp83  RND_Requiem-Patch.esp84  RND_USKP-Patch.esp85  RND_Dragonborn-Patch.esp86  XFLConfig.esp87  XFLDialogue.esp88  XFLPanel.esp89  XFLPlugins.esp8A  dD - Realistic Ragdoll Force - Realistic.esp8B  Reanimate FX.esp8C  FireAndIceOverhaul.esp8D  WATER.esp8E  WATER Plants.esp8F  WATER DG.esp90  WATER DB.esp91  WATER Falskaar.esp92  Bijin Warmaidens CBBE One esp.esp93  CollegeOfWinterholdImmersive - ELnFX Patch.esp  [Version erts]94  DragonCombatOverhaul - Requiem Patch.esp95  Bashed Patch, 0.esp

As well as this issue, I'm getting a CTD when trying to enter the bannered mare in Whiterun. I've tried a few times now.

I got the same thing. It was fixed when I got rid of Populated cities.

I have a lot of NPC mods, and that was just too much activity spinning up on cell entry to the Bannered Mare interior cell.

packages are being evaluated, wet and cold evaluating, frostfall being evaluated, cloaks, etc. for every NPC, I guess.

I have an i7 processor, but still...

hmm.. I see. thanks guys.

Are there any ini tweaks that I could use to utilize my i7 3770k quadcore cpu or my 32 gbs of ddr3 ram? Otherwise I may have to remove some mods as you say. Which ones would be good to remove? interesting npcs is probably on of the guilty, but I can't play without that one. hehehe

It's not 'Interesting NPCs.' It's more likely 'Populated Cities.' It's not 'how many NPCs is add in total', but how much stuff is added to any given cell or zone. Moreover, just because two mods adds 'more NPCs' does not mean they do it the same way. PC's NPCs are (re)spawns, generated on cell loading, whereas NPCs from INPCs are mostly unique actors and persistent refs, and no more than a handful of them can be found in any interior cell. You should start making saves only in interior cells, not in city zones. See if that helps to mitigate the issue. If this is happening a lot when you fast travel or simply trying to enter a city, then you should uninstall PC because it's a sign that your system (or even the game engine itself) can't handle PC + you other mods. If you have trouble loading save games you made in the wilderness, then the issue has nothing to do with these mods at all.

You know. That's the same kind of problem I was getting with Open Cities installed - massive ILS issues combined with Bannered Mare crashes on those occasions where Whiterun actually loaded. You don't have OCS loaded though.... interesting.

This is awesome stuff, thanks. I don't have populated cities, I believe the only npc adding mods are interesting npcs and inconsequential npcs. But I could be wrong. Perhaps having them both together could have a taxing effect?

I think ripple's advice to narrow down the issue (exteriors, interiors, both?) is a really good idea. The first question that I had when I read your post is: where is it happening? Outside In cities, in dungeons, in city buildings--where? Figuring that out might lead you to an answer.

But it sounds like you've got a high-end rig, so there are a couple of things you can try:

Edit your Skyrim.ini file to help with scripts:

And http://www.creationkit.com/INI_Settings_(Papyrus) of these settings, which you should read before you make any changes. With your issue, it may be worthwhile trying the fPostLoadUpdateTimeMS setting from the "Not So Conservative" list above, even if you otherwise use the "Conservative" option.

Also, you should backup your ini file before making changes. If you run into serious problems, you can delete it, launch Skyrim from the default Skyrim launcher, and it will recreate a default ini for you.

The other thing you might try (long-shot) is http://skyrim.nexusmods.com/mods/38649//?. This is a version of ENB for only splitting off Skyrim's graphics memory into a separate process (and fixing a few bugs). It doesn't change how the game looks. So you'll have 800MB or so for your TESV process, and another 1 - 3GB in the enbhost process, which is essentially your textures. This will only help if your problems are related to memory issues, though. Since ENB added this feature, I've had fewer crashes, but longer load times, so keep that in mind.

EDIT: Removed double post.

My system spec is 4GB ram, 7850 2GB, Core2Duo 3.0 GHz, Win 7, running Skyrim in 1680x1050, everything on high settings except shadows (on medium). I am running 160+ mods including 'Interesting NPCs', the hi-res DLC, and aMidianborn's armour/weapons textures. I average 40 FPS in the Whiterun Market....so...this could be an issue with your system (as in you might need to close background processes before launching the game, defrag your HD, that sort of stuff) rather than mods related. You can try turning off AA and AF and use FXAA injector instead. However, I also noticed you have a number of 'city overhaul' type mods. Some of those mods can add a ton of stuff to the game and cause the 'indefinite loading screen' issue in cities (but only in cities, not when you fast travel to places that are not edited by those mods). You also didn't list if you are using any texture overhaul type mods. It's important that you try to figure out the 'location' of the saves that you have issues with, and the locations of the fast travel where you encounter this issue. If we can't narrow down the issue, all we can do is make 'blind guesses' and that won't really help.