IMO:
Since in the Gameinformer article they said that there were certain parts of FO:3 that they would love to implement some aspects of that game into Skyrim.
I think it'd be awesome to have something like Oblivion's prison escape and FO:3's entry into the ruined D.C. cityscape mixed. Since they already said that they were going to stick with the "prisoner-gets-divinely-lucky" prison break and since it is Skyrim...
The prison that the PC is kept in is a deep subterranean prison within a distant mountain in an almost unsettled part of the mountain range. The escape route once that scene plays out takes the PC into a series of twisting caverns and tunnels ranging from subterranean aquifers to frozen glacier-like tunnels, to a vast underground canyon system glimpsed only as the PC crosses a long-forgotten, rotting rope bridge. Upon exiting the tunnel system, the PC's eyes take a couple seconds to adjust then he is awed by the view from a mountain cliff-pass over the valley below.
The PC sees down the mountain side at the forest hundreds of feet below. As the forest stretches into the valley, we see where an underground river bursts from the mountainside and cascades in a brilliant waterfall that crashes into the valley floor and then flows into a canyon that divides the valley floor like a gigantic sword slash. Along the edges of the canyon is a city/village/metropolis built as well into the sides of the cliff. You can barely see the systems of the rope bridges and rope & pulley systems used to traverse the cliffs. From the settlement, you can see a paved road twisting through the pass out of the valley towards some distant city.
This would be a very cool opening IMO. =)

bliviongate: