I'm pretty certain my issues are memory issues being caused by skyrim being a 32-bit app with limited 32-bit addressing trying to talk to the GPU drivers which like the OS are 64-bit, and thus nothing to do with save games. It's pretty random overall, as this so far has done nothing to rectify memory issues it'll continue to happen every ~20 minutes to 2 hours. 70~80% of the time, these crashes are also preceded with graphical anomalies, primarily unloaded textures.