I know how you feel. Mine got all kinds of stupid bugs and glitches post patch on PS3.

ED-E gets stuck, it lags a bit more and it's stopped autosaving sometimes. Among others. When a companion and ED-E walk thorugha door or ona narrow walkway, ED-E gets stuck and you have to dismiss him to get the other person moving!
Among the worst ones is this.
It changes your ncr rep and other reps for no freaking reason to neutrel at points in the main quests. It's a COMPLETE AND TOTAL PAIN IN THE ASS! You spend ages raising your ncr rep and then when you need it most it turns it to freaking neutrel!
And NO, it's nothing to do with Don't Step On The Bear! That quest does'nt take that much rep it takes you from idolized the freaking neutrel!
Last time I was idolized by the ncr right till You'll Know it when It Happens, then in the middle of hoover dams bridge it suddenly turns to freaking neutrel for no freaking reason!
I had'nt even done anything beyond destroy the BoS bunker and say the barest minimum possible when I did the horrible CL trophies, for the trophies only, when it turned to nuetrel for no reason!
I got attacked by a CL assasin squad when it was at liked with CL too! They really, really overdid the CL assasin squads, for strength and the ammount!
It does'nt know what the hell it's doing! Reps change or don't make sense. One time your vilified by the powder gangers at the start, another your neutrel! Same for great kahns!
Beyond The Beef, that quests a freaking joke!
It's like the games coming apart!
That was a bad patch.
If that pathetic excuse for a game engine has ANY PART in the next fallout game, the people making it are complete and utter idiots! It is the worst game engine I have EVER SEEN ON ANY GAME EVER!
I really, really hope the next game engine is completely new and nothing to do with that horrible lag, crash, freeze glitch, bug monster!