Right now I am using a combination of perk overhauls such as Ace Combat + Mighty Magic + Stealth Skills Rebalanced + Smithing Overhaul Redone + Path of Shadows Alchemy...

Works well but I thinking of dropping all of those just so I can harmonize, plus a lot of those other mods are no longer actively updated. Though if there isn't really a problem with any of them "and I haven't found there to be" Is there any reason to change?

With Skyrim Redone do I only really need compatibility patches for mods that add bows, kind of like ACE combat archery? Or are there other conflict/compatibility issues I should consider?

SPERG's auto perk system seems a bit alien... I don't really know of anything else.