Yes, but it depends on the quality of the perks.
I can name about ~25 perks from Fallout 3 that are freaking useless, so I'd never take them. And just like that, all my characters are the same.
We need perks that make each and every one of the 18 skills unique in some way, and I'm not quite sure how they're gonna do that. 280 divided by the 18 skills is 15 perks per skill. I somehow doubt they can come up with 15 perks for marksmanship or illusion (what effects would they have), which would mean that any character would have an easy time mastering these skills via perks on the side. And personally, if the perks for illusion and such are nothing but spells, then I honestly think I'd be disappointed. So yeah, if the one handed skill, block and armor skills provide quality perks, whereas the marksmanship skill only has one or two good ones and the magic skills only provide spells, then we've got a problem. Everyone would neglect the magic perks but still use the skills while getting the combat perks for stat boosts.