Its funny, the first time I looked at TES (with an eye for Fallout3 using the engine), I noted that birth signs were effectively traits, and that permanent spell effects were effectively perks.
I voted yes, because if handled well, it would allow for greater PC variety, but since the setting is high fantasy, I'd like to see "perks" (by some other name) implemented as training or life experience (including getting cursed).
(It would be hard not to compare them with D&D feats though).
**I'd also like a version of the HC mode ~though nothing to do with dehydration or delayed healing (that should be default [IMO] for any healing other than magical, though magic would be the most used healing ~sometimes you just don't have it).
***Even so... delayed healing isn't so bad or implausible with a healing potion... It could be neat if it needed a little time to work (it's magic).