Except for how they look, differences in gender (not in the case you sighted but when it applies, and for race. Sort of like life where we all start out with an even start and build on our own personal attributes as we age and as we gain experience.
But in real life we don't all start out the same . . . every person has inherent strengths and weaknesses. And Skyrim leaves that out. In real life, not every person is naturally gifted in music, or in athletic abilities . . . we all have unique differences, even from a very early age. Plus, as I'm personally all too aware of, there are birth defects and injuries that can result in disabilities (which each come with their own strengths and weaknesses).
In the beginning of the game, your character is an advlt (like 20 years old or more) . . . so they would have 20 years worth of experience . . . presumingly 20 unique years of experience . . . so they should have some learned skills, along with innate abilities (they should be better than average at some things and worse than average at other things). Todd stated that an average game might last 200 real hours, during which you might level up 50 times (and gain 50 Perks). 200 real hours = 250 game days (based on a 30 Timescale) . . . which is less than 9 months. So my 20-year-old starting character would have no skills, no education, nothing they are good (or bad) at . . . yet during the 9 months of game time that I'm playing the game, they will suddenly be able to excel at any skill that they use. I'm having a LOT of trouble wrapping my brain around that kind of logic.
Some things of course will be better suited for a woman or a man or to one of the many races. A Nord will still start out stronger so he/she should be good with heavy armor. But as for classes, you get to choose and then play the part that you choose. If you decide you want to be good with a bow at the beginning of the game, use a bow. Why is choosing it as a bullet item better than choosing it as an actual major skill by using it?
And if you run out of arrows and pick up a sword, you'll soon become just as good with a sword . . . even if I wanted my character to be naturally better with a bow. I cannot create a character with any inherent abilities (along with opposing inherent weaknesses). In real life, every person who picks up a basketball and practices shooting baskets does not become a basketball star.
I don't know for sure but in my head it sounds like a pretty awesome change that I am more than willing to play through once to see how it works before I decide I won't like it. I'll just have to see how it plays out. It's certainly something I would like to know much more about.
We've already tried this out . . . it was part of Oblivion's Tutorial . . . and it didn't work very well (most players didn't keep the class that their game play resulted in).