While we all knew this from some older interviews Bethesda did a long time ago, its interesting to see Pete restate it in regards to Fallout 4.
http://www.digitalspy.com/gaming/news/a656742/nothing-is-sacred-at-bethesda-game-studios-says-ceo-pete-hines.html#~piPejeMZgNvAg4
Speaking to Digital Spy, Hines said that there are no sacred pillars when developing games like Fallout and that the team instead chooses to 'blow up everything and start all over'.
"I think these guys really do believe in the idea of every time you make a game you've got to blow up everything that you did and start all over," he said.
"Because if you start with some base assumptions like, 'Well of course we have to have this', pretty soon you're going to find out that you're not really breaking new ground, you just end up iterating, because you're going to find all these sacred pillars.
"I think Bethesda Game Studios has this culture of, 'Look, there are no sacred paths. We don't have to do anything, so what should we do?'"
Hines said that this approach leads to new experiences in games, like Fallout 4's world building and item crafting.
"If you make too many assumptions to begin with, I don't think you ever make that leap, so I think [Bethesda Game Studios is] very good at playing without a net, and letting go and taking a chance."
During the same interview, Hines said that the company is aiming for shorter release campaigns, after deciding to announce and release Fallout 4 in a five-month period.