Ok, so i've installed a few MODs. Ran the BOSS Load Order sorter (from within FOMM), then just to be sure I ran the Official BOSS utility afterwards:-

From FOMM:---

FalloutNV.esmDeadMoney.esmHonestHearts.esmOldWorldBlues.esmIWS-Core.esmNSkies - Vanilla Edition.esmNVR-Strip.esmPrimary Needs HUD.esmProject Nevada - Core.esmProject Nevada - Equipment.esmELECTRO-CITY - CompletedWorkorders.esmELECTRO-CITY - Highways and Byways.esmDarNifiedUINV.espNVR-NPCs.espNVR-ELECTRO-CTIY_Patch.espNVR-Version_10.espProject Nevada - Cyberware.espNewVegasBounties.espNewVegasBountiesII.espIWS-Core-Patrols.espIWS-Core-Guards.espIWS-Core-Civilians.espIWS-AS-MedSpawns.espIWS-AS-NoInteriorSpawns.espProject Nevada - Rebalance.espVurt's WFO.espTotal active plugins: 26Total plugins: 26

And from BOSS Log:---

    FalloutNV.esm        Note: Masterlist Revision: 3118 (Aug 14 , 2011)    DeadMoney.esm        Bash Tag suggestion(s): {{BASH: Deflst}}    HonestHearts.esm    OldWorldBlues.esm    IWS-Core.esm        Bash Tag suggestion(s): {{BASH: Delev}}        Note: Loaded early to let other mods override spawn points if needed.    NSkies - Vanilla Edition.esm        Bash Tag suggestion(s): {{BASH: C.Climate, C.Light}}        Note: Choose only one of NSkies URWLified.esm, not both    NVR-Strip.esm    Primary Needs HUD.esm    Project Nevada - Core.esm        Requires: New Vegas Script Extender    Project Nevada - Equipment.esm        Bash Tag suggestion(s): {{BASH: Delev, Invent}}        Requires: New Vegas Script Extender and Project Nevada - Core.esm    ELECTRO-CITY - CompletedWorkorders.esm    ELECTRO-CITY - Highways and Byways.esm    DarNifiedUINV.esp    NVR-NPCs.esp    NVR-ELECTRO-CTIY_Patch.esp    NVR-Version_10.esp    Project Nevada - Cyberware.esp        Requires: Project Nevada - Core.esm    NewVegasBounties.esp    NewVegasBountiesII.esp    IWS-Core-Patrols.esp    IWS-Core-Guards.esp    IWS-Core-Civilians.esp    IWS-AS-MedSpawns.esp        Requires: New Vegas Script Extender        Note: Only use one of the spawn .esp's    IWS-AS-NoInteriorSpawns.esp    Project Nevada - Rebalance.esp        Requires: Project Nevada - Core.esm    Vurt's WFO.esp        Incompatible with: Vurt's Trees & Grass.esp

Addidtionally I have installed DarnsUI and NMCs LARGE Texture Pack.

Now If I run the game as is i get a CTD anywhere from 2-15 minutes after playing, I ran the 4GB Enabler (which I'm not sure that I need anyway) and that "seems" to have stopped the CTDs .

My PC Specs are as follows:-

Windows 7 64 Bit
Intel Core i7 980X 3.33GHz (Gulftown) Extreme Edition
Asus X58 Sabertooth TUF Intel X58 (Socket 1366) DDR3 Motherboard
EVGA GeForce GTX 580 SuperClocked 1536MB GDDR5 PCI-Ex
Corsair Dominator GT 6GB (3x2GB) DDR3 PC3-15000C9 1866MHz Triple Channel
Asus Xonar D2 7.1 PCI Sound Card

So I really shouldnt have problems running the game with the MODs/ Texture packs that I have currently installed, and as far as I'm aware the 4GB enabler isnt necassary on a 64 Bit system (or maybe i'm wrong there).

Any help you guys can offer would be appreciated.

Thanks.

You are running the New Vegas Script Extender mod with the lastest update (beta 9.(something) ) correct?

Yup:-
New Vegas Script Extender v2 beta 9

IWS is notorious for its CTD causes. At least, so i've heard around the boards, and have experienced in my game. I recommend you replace it with DFB - Random Encounters, which has and end effect similar to IWS.

Also, you may want to get the newest http://www.ravenmodding.terminal47.net/, but that's just my opinion.

And then there's the option to run Wrye Flash, but again, mainly an option, not a requirement (though it may as well be one, as useful as it is).