I think a better idea would be to have fallout in NYC, I want to see the Statue of Liberality destroyed and maybe the cloverfield monster could be in it (joke) but seriously i want to see the diverse effects the radiation would have on sea life like land sharks and other things among that.
Where some young man stole plans for an advanced steam engine from a technologically advanced race, which made the humans flourish in settlements because of said technology. There also would be other "mutants", who generally live longer on the average, who tend to commune with nature due to an art they mastered called "magick".
Why ,, this sounds exactly like Arcanum from Troika( the studio founded by the guys who originally made F1)
If they can make FO4 an improvement over FO3 in terms of dialog, depth of choices within quests (or quest depth, period) and storytelling...than sure, I'm up to see what they can do. Improving their engine and making animations relevant to this century wouldn't hurt either.
If they make FO4 anything like FO3, then my vote is "No. Enough already. Let it rest in peace."
the game has nothing to do with real history it diverges in the 50s so it would not have anything to do with our timeline