Hi, just come back to Fallout 3 after a lengthy break.
Installed a load of Mods (seeing as there is so many good ones now) but the game is crashing like mad.

I remember the game used to be a bit tempramental a while back but this is like every few minutes.

It's got to the point now where i have to Quicksave (Via C.A.S.M) every few minutes just in case, now i'm not a big fan of Quicksaving all the time as i feel it takes away the suspense of travelling in a dangerous environment.
The thing is, i should be worried about Raiders and Munants, not CTDs.
So if someone could please take a look at my Mod List/Load Order it would be greatly appreciated.

[X] Fallout3.esm[X] Anchorage.esm[X] ThePitt.esm[X] BrokenSteel.esm[X] PointLookout.esm[X] Zeta.esm[X] CRAFT.esm[X] CALIBR.esm[X] Destruction.esm[X] CubeExperimental (EN).esm[X] tubrrCompound.esm[X] DCInteriors_ComboEdition.esm[X] FO3 Wanderers Edition - Main File.esm[X] Mart's Mutant Mod.esm[X] Xepha's Dynamic Weather.esm[X] Enhanced Weather - Rain and Snow.esm[X] DarNifiedUIF3.esp[X] PreWar Book Titles and Perks.esp[X] HeirApparent.esp[X] NotSoFast.esp[X] PLweightadjust.esp[X] IntoTheDeepWoods.esp[X] Destruction - CP - Fellout.esp[X] Destruction - DLC - Statics.esp[X] Destruction - DLC.esp[X] Destruction - Main - Statics.esp[X] Destruction - Main.esp[X] CanterburyCommonsEmbiggened.esp[X] CASM.esp[X] RockopolisRebuilt.esp[X] ShadySands.esp[X] tubRRCompound.esp[X] FO3 Wanderers Edition - Main File.esp[X] FO3 Wanderers Edition - DLC Anchorage.esp[X] FO3 Wanderers Edition - DLC The Pitt.esp[X] FO3 Wanderers Edition - DLC Broken Steel.esp[X] FO3 Wanderers Edition - DLC Point Lookout.esp[X] FO3 Wanderers Edition - DLC Mothership Zeta.esp[X] FO3 Wanderers Edition - Followers Enhanced (BrokenSteel).esp[X] Mart's Mutant Mod.esp[X] Mart's Mutant Mod - DLC Anchorage.esp[X] Mart's Mutant Mod - DLC The Pitt.esp[X] Mart's Mutant Mod - DLC Broken Steel.esp[X] Mart's Mutant Mod - DLC Point Lookout.esp[X] Mart's Mutant Mod - DLC Zeta.esp[X] Mart's Mutant Mod - Natural Selection.esp[X] Mart's Mutant Mod - Tougher Traders.esp[X] Mart's Mutant Mod - Increased Spawns.esp[X] Mart's Mutant Mod - No Abominable Mutants.esp[X] Mart's Mutant Mod - No Corpse Flies.esp[X] Mart's Mutant Mod - No DLC Increased Spawns.esp[X] Mart's Mutant Mod - No Floaters.esp[X] Mart's Mutant Mod - No Geckos.esp[X] Mart's Mutant Mod - No Ghoul Raise.esp[X] Mart's Mutant Mod - No Skeleton Decay.esp[X] Mart's Mutant Mod - No Stalker Creatures.esp[X] Mart's Mutant Mod - No Wanamingos.esp[X] Mart's Mutant Mod - Soft Unleveler.esp[X] Mart's Mutant Mod - Zones Respawn.esp[X] Mart's Mutant Mod - FWE Master Release.esp[X] Enhanced Weather - Rain and Snow in Fallout.esp[X] Xepha's Dynamic Weather - Main.esp[X] Enhanced Weather - REBOOT.esp[X] Xepha's Dynamic Weather - Broken Steel.esp[X] Enhanced Weather - Sneak Bonus during Storms.esp[X] Enhanced Weather - Weather Sounds in Interiors.esp[X] Wasteland Weather Overhaul .9.esp[X] merged patch.esp

Thanks in Advance.

[X] Mart's Mutant Mod - Natural Selection.esp
[X] Mart's Mutant Mod - Tougher Traders.esp
[X] Mart's Mutant Mod - Increased Spawns.esp
[X] Mart's Mutant Mod - No Abominable Mutants.esp
[X] Mart's Mutant Mod - No Corpse Flies.esp
[X] Mart's Mutant Mod - No DLC Increased Spawns.esp
[X] Mart's Mutant Mod - No Floaters.esp
[X] Mart's Mutant Mod - No Geckos.esp
[X] Mart's Mutant Mod - No Ghoul Raise.esp
[X] Mart's Mutant Mod - No Skeleton Decay.esp
[X] Mart's Mutant Mod - No Stalker Creatures.esp
[X] Mart's Mutant Mod - No Wanamingos.esp
[X] Mart's Mutant Mod - Soft Unleveler.esp
[X] Mart's Mutant Mod - Zones Respawn.esp

Start with removing all of those. There is a built in menu in the FWE-MMM patch that allows you to control all those elements. Rebuild your merged patch afterward and see if that helps.

Also, if you have a multi-core CPU look into the Fallout.ini tweaks that help with that.

Two weeks ago, I was in pretty much the same situation; the game was almost unplayable due to numerous CTDs, although I had followed the advice given in the http://www.fallout3nexus.com/downloads/file.php?id=13111 and "http://modsreloaded.com/how-to-reduce-crashing-using-fo3edit-t2473.html".

Then I realized that the good old "Wryebash" of Oblivion had been ported to Fallout 3, at least to some extent: it's called http://www.fallout3nexus.com/downloads/file.php?id=11336 and though I didn't expect at first to see any difference in reliability between a merged and a bashed patch, I was soon pleasantly surprised.

But there were still too many problems for my taste, so I added the http://cs.elderscrolls.com/constwiki/index.php/TES4Edit_Cleaning_Guide to see if it was of any use in Fallout 3 too.

Well, it was. The automatic cleaning done with Fo3edit is already a great way to reduce problems, add some manual clean up and CTDs are, well, not exactly a thing of the past, but I have played now for a couple of days and had to restart the game only twice when it became sluggish (and I am already positive that MMM RC6 is the culprit in the troubling area). Of course, Mod Cleaning isn't without dangers, so you should have a pretty good idea what you're doing. But in my game, it added immensely to the stability I was looking for.