Because nearly all Misc items are weightless, it is the one area of Inventory that gets seriously bloated. Further, many things can't be offloaded. I am quite tired of going into Inventory just to find what in Misc I just vacuumed up. "Oops! Was that a holotape I just saw? What was the title?"
Bring back the key chain! Do I really need to have 25+ keys scattered throughout the list?
Holotapes -- which, frankly, is a stupid label for things with no Visual component -- should be grouped together.
Magazines & Comic Books
Video Games
Etc.