It's a bit like OBSE breaking the DB quest, it really shouldn't happen - pluggy only adds functions and hooks into the DirectX stuff (the source of the crashes with the HUD version). Did you have a mod that touched the DB stuff, and required pluggy
Just noticed your signature.
Ref other mods - None that I am aware of utilizing any pluggy functionality.
Arthmoors http://www.tesnexus.com/downloads/file.php?id=31773
Khettiennas http://www.tesnexus.com/downloads/file.php?id=22135
The last one will use cobl for placement of some items, but that is a recent installment and was not part of the equation when we experienced the same problem before last week.
Edit: And the only overhaul in use, http://www.tesnexus.com/downloads/file.php?id=35265 uses vanilla resources completely, I only mention this because the subject of the murder is a TNR character added by T.I.E.
Edit2: For completeness of report - Current list of BAIN installers, the ones you will be interested in starting at 028 .....
Spoiler Bain Packages:
000 - ==--UOPs--==
++ 001 - 1.Unofficial_Oblivion_Patch_v3_2_0_Manual_BAIN-5296.7z (BCBA7B56) (Installed)
++ 002 - 2.Unofficial_Official_Mods_Patch_v15_BAIN-9969.rar (59895567) (Installed)
++ 003 - 3.Unofficial-SI-Patch-v1_4_0-BAIN-10739.rar (79CE866D) (Installed)
004 - ==--Sounds--==
++ 005 - Louder_Nirnroots-5277.rar (1C92F999) (Installed)
++ 006 - AS_Rain_and_Thunder_Sounds_V1.7z (DF3DBAB0) (Installed)
++ 007 - Quiet & Whispered Feet MAX.rar (E8212F8E) (Installed)
++ 008 - Ambiant_Sound_FX_1-2-29676.rar (93165CB5) (Installed)
009 - ==--Land-LOD-Weather--==
++ 010 - 1.Bomrets_Detailed_Normal_Maps_for_Vanilla_Version_1_1-18430.rar (19757949) (Installed)
++ 011 - 2.Diverse Grasses 0.6 - Main.7z (082DA354) (Installed)
++ 012 - 3.LowTriPolyGrass-33403.7z (C5ADC3C6) (Installed)
++ 013 - 4.LowPolyTrees-33414.7z (9AA85BC1) (Installed)
++ 014 - 5.RedBag_-_Fog-33424.rar (694FDFF4) (Installed)
++ 015 - 6.Animated_Window_Lighting_System_-_Meshes_v5-3-5-19628.7z (ACFDDEAD) (Installed)
++ 016 - 7.AWLS_-_Brumbek_Mixed_Textures_v5-2-0-19628.7z (9D61BD69) (Installed)
++ 017 - 8.RAEVWD_v1_8-20053.7z (CC621199) (Installed)
++ 018 - 9.RAEVWD_SI_Edition-20053.7z (2E433124) (Installed)
++ 019 - 10.RAEVWD_Darker_Regal_IC_Texture_Pack-20053.7z (911475E6) (Installed)
++ 020 - 11.RAEVWD_SI_Bomret_Textures-20053.7z (ABBE189F) (Installed)
++ 021 - 12.Unofficial_Patch_Supplementals-v3.3.3-27710.7z (B22A6E3A) (Installed)
++ 022 - 13.Phinix_Waterfix_v2-6680.zip (66703519) (Installed)
++ 023 - 14.ImprovedSignsComplete-9498.rar (7B1F6919) (Installed)
++ 024 - 15.Real_Wood_Road_Signs_Full-25429.rar (9FF09A61) (Installed)
++ 025 - 16.Unique_Signs-25314.zip (FC0A6D23) (Installed)
++ 026 - 17.All_Natural_v1_0-18305.7z (FEE597A7) (Installed)
++ 027 - 18.New Roads & Bridges.7z (7C700E60) (Installed)
028 - ==--House-Dungeons-Castles-Quests--==
++ 029 - Better_Dark_Brotherhood_Sanctuary_v3-01-BAIN-22135.7z (252A2B65) (Installed)
++ 030 - Better_Abandoned_House_v1-22-BAIN-25319.7z (166C4B5C) (Installed)
++ 031 - Better_Benirus_Manor_v4-6-BAIN-18054.7z (90F144F9) (Installed)
++ 032 - A_Brotherhood_Renewed-v1.09-31773.7z (CEE4E8C7) (Installed)
++ 033 - Aleswell_Cottage-28702.rar (A17331C6) (Installed)
++ 034 - BravilBridgeCottage.7z (3F55268C) (Installed)
++ 035 - RoxeyCottage.7z (D578DFC4) (Installed)
++ 036 - Faregyl_Village-21562.rar (F182678F) (Installed)
++ 037 - Molapi-33462.7z (F26CA663) (Installed)
++ 038 - Oubliettev1.2.rar (7AEB8C14) (Installed)
++ 039 - The_Ayleid_Steps_3_4-16316.7z (AFBC1590) (Installed)
++ 040 - Vergayun-26643.7z (EAC246C4) (Installed)
++ 041 - Feldscar-v1.05-30000.7z (FC78DFC4) (Installed)
++ 042 - Shadowcrest_Vineyard_COBL-22810.7z (C24B9C58) (Installed)
++ 043 - NRB4_Shadowcrest_Vineyard_Compatibility_Patch-20218.7z (8EEC0435) (Installed)
++ 044 - TIE-v1.41-35265.7z (DBEF5C74) (Installed)
++ 045 - Mudwater_V_1_2_Full-35434.7z (ECC5DCC1) (Installed)
++ 047 - Darkness Hollows1.4.7z (506F5C8B) (Installed)
048 - ==--Body-Race--==
++ 049 - 1.Cobl_172-21104.7z (BFECAEE3) (Installed)
++ 050 - 2.Cobl_Cosmetics_Res_01-21104.7z (C1254BEC) (Installed)
++ 051 - 3.Cosmetic Compilation Revived - Capucine-17042.7z (00C83C68) (Installed)
++ 052 - 4.Exnem-Female-Eyecandy-nvde-v1-10171.7z (58411DC0) (Installed)
++ 053 - 5.HGECBody_v1dot21-BAIN.rar (C530A9C0) (Installed)
++ 054 - 6.OFF_1_1_7ZIP-35487.7z (FB9504E5) (Installed)
-- 055 - 7.Ozmo Hires 2048 for HGEC - Mixed BAIN.7z (86A939F6) (Not Installed)
++ 056 - 8.RobertMale_v5_plus_Average_BAIN-25365.rar (19FA4533) (Installed)
++ 057 - 9.TGND_Release_2.1_BAIN-30914.rar (BD372531) (Installed)
++ 058 - 10.Foxs_Female_Argonian_textures_for_Exnems_body_v11-10506.rar (C068570D) (Installed)
++ 059 - 11..Tabaxi_Version_2-9870.7z (40A7B16F) (Installed)
++ 060 - 12.Khajiit_Fix-31156.7z (F067285F) (Installed)
++ 061 - 13.SUN_IB_Textures_v1.5-BAIN-33354.7z (1F9218E3) (Installed)
++ 062 - 14.Exlorians_Khajiit_Tail_for_HGEC-33745.rar (5E9DD6F1) (Installed)
++ 063 - 15.The_n_Dywyll_Elves-35397.7z (AB7F2FE4) (Installed)
++ 064 - 16.SP_Hair_Pack_Beta_Ver_1_0-30707.7z (4640AFFD) (Installed)
065 - ==--Companion-Creatures--==
++ 066 - TIE Cats Full v1.0-34872.7z (07AB2D2E) (Installed)
++ 067 - slofs_horses_base_2-24312.7z (3EFC924F) (Installed)
++ 068 - Espless_Slofs_Horse_Replacer-27675.7z (39EF0C00) (Installed)
++ 069 - Benjamin_the_donkey_-_pimped_up_version_-_small-33618.7z (0094F848) (Installed)
++ 070 - Companion_Vilja_ver_2-28977.7z (BF7DB802) (Installed)
++ 071 - Companion_Vilja_ver_2_3_2-28977.7z (AD06FACA) (Installed)
++ 072 - Vilja_Customization_Pack-28977.7z (A9C6F328) (Installed)
++ 073 - Companionfriendly_Inns_0_9-33475.7z (582803D2) (Installed)
++ 074 - Deadlier_Creatures_V2-31882.rar (09BC037C) (Installed)
075 - ==--Armour-Clothing--==
++ 076 - Dark_Sisterhood_for_TGND-32970.7z (D4760C14) (Installed)
++ 077 - Kogane_Ranger_Armor-30916.rar (3F01A9F9) (Installed)
++ 078 - Lingerie_and_Underwear_for_TGND-33113.7z (8AD00C8D) (Installed)
++ 079 - Mithris_HGEC_v2_with_TGND-32958.rar (C6664024) (Installed)
++ 080 - Phasmatis_Rogue_Leather_for_TGND-32999.7z (16252534) (Installed)
++ 081 - Shell_of_the_Artificer_1.5_RobM_TGND-33087.7z (6B4D4A6E) (Installed)
++ 082 - TGND-Athol_Brose_v1_1-31246.rar (2A78FA8F) (Installed)
++ 083 - TGND-Corsets_of_the_Rose-Fixed-31331.7z (41DBB352) (Installed)
++ 084 - TGND-Featherwynd_-_Amazon_Priestess-Patched-28151.rar (C7BC3CCF) (Installed)
++ 085 - TGND-Zertualpro_Sonja_Underworld_armor-25734.rar (122147B4) (Installed)
++ 086 - TGND_Sister_of_Eisen.rar (6DE7A087) (Installed)
++ 087 - TGND_Witch_Queen_Ritual_Robe-31026.rar (354E7B06) (Installed)
++ 088 - slofs_giger_armour_2-24756.7z (C0E42CC5) (Installed)
++ 089 - Dwemer_Spectacles-5198.rar (04C823F3) (Installed)
++ 090 - Neck Seam Concealer Version_1_2-18669.rar (E942D40B) (Installed)
091 - ==--Weapons--==
++ 092 - SothaDagger_-_The_Ornate_Dwemer_Blade-24236.rar (A9231713) (Installed)
++ 093 - Nicos_Tabaxi_Bows_v1_0-17444.rar (41579318) (Installed)
++ 094 - Blade of Woe and Sufferthorn Replacer.rar (92842CB0) (Installed)
095 - ==--Misc--==
++ 096 - slofs_ob_pillow_book_1.1.rar (7A987642) (Installed)
++ 097 - Improved Soulgems for TIE.7z (C70A668A) (Installed)
++ 098 - Better_Potion_Bottles_Reduced_1dot2-14347.7z (93FC23BE) (Installed)
++ 099 - VAs_Better_Gold_with_No_Menu_Icon-5122.rar (DDF03442) (Installed)
++ 100 - ElvenMapComp1-NRB_Map-32006.7z (85E05093) (Installed)
++ 101 - Sensual Walks Patch ESPs v6.8.2.7z (2FB72E18) (Installed)
++ 102 - Display_Stats_1_3-31855.rar (235DAD1C) (Installed)
++ 103 - Clocks_of_Cyrodiil-11778.7z (0E92A616) (Installed)
++ 104 - Streamline_31_and_patch_BAIN-22170.7z (F4DFA50A) (Installed)
105 - ==Last==
And in all versions used of pluggy - I have never needed to enable the HUD. So the dynamic link libraries have remained the same name as downloaded.
OBSE v0019 stable installed. Previously used 0018b6.
Current OBSE thread seeing as you have been absent for a while http://www.gamesas.com/index.php?/topic/1131224-relz-oblivion-script-extender-obse-0019/