I'm personally hoping it will be more like giving your weapon a deadly coat, which can last for a set amount of time rather than JUST a single use. Like, when you poison your blade, it would be good for say, 15-30 seconds or X # of hits, then the poison would loose its toxicity, dry up, or just wear off the blade. Like in real life, some poisons coat an entire blade, and will last until the mixture breaks down. Others are good until they dry up and basically cant enter the body. Some are so volitile/hard to make, you only dip the very tip, and will get used up on the first strike - which is how all of oblivions felt and was lame - no variety.
So any word on this at all? I'm curious to know.