I would have to say I take advantage of all of the combat skills to switch things up. I lean to One-Handed more than Two-Handed because of the diversification.
My second choice is whichever defense I go with. Currently Heavy Armor.
Third, I would have to say the crafting skills to boost my character.
After that, I find sneak and Illusion to be good tools.
Then I would prefer all of the magic schools that I haven't mentioned. They come in handy.
The rest that's left over are just extra.