How isn't it dumbing down. If I can only make potions/poisons at certain locations, with no variable in the equipment I use. Same with repairing, if its stationary. Seems like they not only took the good stuff from the newer Fallout's (the difficulty and leveling, perks, etc.), but the bad as well (linear crafting/repairing, less armor etc.) If there truly isn't any portable Repairing/Alchemy.
Maybe Im RPing a pure Alchemist, or a Druid with basic Wort-craft and M/P Alchemy? I guess those builds may be gone as well?
Let's table the question of whether Skyrim Alchemy is "dumbed down" vs. Oblivion Alchemy until we know all the details.
All we know so far is that you can only perform it in specific locations, there are some reagents involved in addition to standard ingredients, and there also will be 12-20 Alchemy perks.
As for the lack of portable lab - IMO it makes sense for an alchemist to have a lab where he creates all his concoctions, bringing his potions and poisons around with him when adventuring rather than conducting complex experiments in a dungeon with monsters. I do agree, however, that this strongly suggests a greater likelihood of no improved tiers for the equipment. At any rate, perhaps there are some other still unrevealed details that will add some new layers of things we can do with Alchemy.