Portal 2, ME3 and ES:V are my most anticipated games this year. Portal 2 couldn't compete against ES:V in terms of scale, but I have my reasons for eagerly waiting its arrival.
I am waiting for the free-roaming aspect and choices available in the next game by Bethesda. The amount of technology going into making the game as rich and detailed as possible is staggering and I can't wait to see it in action.
I have however got greater interest in the HL universe and hoping that by the end of the portal 2, it may go someway to explain why your character is still alive after 100 years, i.e. did humanity prevail from the combine or are you alone in the world? Who knows HL:Ep3 may come out at the end of the year to explain what happened in greater detail.
Same here.
ME3, Skyrim and Portal 2 are the three big ones on my radar (in that order). Fingers crossed they should all be amazing.
As far as GOTY goes, my guess is ME3 or Skyrim will sweep up most of them.