If you're talking about a gamepad controller...I wasn't even aware there was a left-handed control option in some games. :shrug: I'm a lefty myself and just use the default controls when I use a gamepad, no trouble at all.
Keyboard and mouse is another question entirely. I have my mouse on the left side of the keyboard, so using the standard WASD controls is next to impossible for me. I have to reconfigure the controls to the number pad, and so get rather cross if a PC game for some reason doesn't allow you to customize the controls.