1. More variety in armor/weapons types and design(example: more than one type of daedric armor, like the "faces" in MW),
2. The return of stalrim and nordic equipment
3. Armor/weapons that follow lore(orcish acually being lighter than average steel, and glass have almost no weight, but low itemhealth),
4. Skill requirement in guilds
5. Great House-type of guilds and knight orders
6. Quest that actually have an effect on the world rather than only hearing a few rumors(the quest with the bomb in megaton is a good example),
7. No forced "use this, it's the best in all ways" type of spell since spellmaking is gone.
8. More ways to earn artifacts(in tombs by example)
9. More artifacts
10. No adoring fan or fargoth type of characters
11. More interesting characters
12. An opertunity to work against TG and DB
13. More Evil Guilds
14. More Good Guilds
15. More Neutral Guilds
Just of the top of my head