Sure!
A few things actually, some seedy some not:
1. Have the response to the player based on the players Charisma and lack/presence of the Lady Killer/Black Widow perk. If the player is beautiful or charismatic, the NPC might comment something along those lines. If the player downright gross and not charismatic, the NPC might make a joke at the player or start laughing out loud.
In general the player's appearance (while nakked) should have an impact on the Type of response we get. Ghouls should say something truely obscene.
2. If the player is wearing BoS or Enclave power armor, they might react in some way to that fact - wastelanders would run away or perhaps cower in fear when an Enclave trooper walks into the room, and might start clapping or giving free drinks to someone who looks like a member of BoS. Kinda the opposite of the nakked response, here the NPC would be responding to what they would Perceive the player to be (based on armors/clothing).
3. If the player is poisoned or diseased, the NPC might make a comment about the smell or perhaps scream out, "Plague!" and run off. :laugh: In this respect the NPC would be reacting to the players condition. If the player is close to death, friendly NPCs might have a chance of running up to stabbing stimpack into your arm (imagine that!). Low health is just one physical condition the NPC might see and react to.
4. Use the player's Special's determine a potential reaction to the player. If the player has a super-low Agility, the NPC might say, "Didn't I see you trip up the stairs last week? Hahaha way funny". Or perhaps a low Intelligence might illicit comments about the player needing a clue, or perhaps a chance of handing the player a skill book and wishing him the best of luck with that clue, or something :hehe:
This could go a long, long way - and frankly improving NPC reactions is something that Bethesda is focusing on right now (per Todd Howards latest interview). If done right this would literally improve immersion and make the wasteland seem more real.
Good luck with this! I may post some of this in the New Vegas forums as things we would like to see as well if you don't mind.
Miax