My current save is 11MB in size and I haven't had any weird issues. Yet.
One of my earlier characters took a trip to Canterbury Commons to do a quest and when she arrived no one was there. In the centre of town was this large square pit with a pool of water at the bottom. Looking down and
all the townspeople were swimming in it. So, for fun I jumped in, too :laugh:
That was just a mod thing. Something I'd installed recently. It wasn't even a mod that had anything to do with CC. Whatever it was didn't last long, anyway. Not many are permanent fixtures in my load order.
Back when Point Lookout first came out I accidentally had that loading before Broken Steel. That caused Fort Independence and most of Fairfax Ruins to vanish completely, due to a massive chunk of landscape just not being there. Switching those two DLC's around the other way and reloading fixed it.
I get the odd super-strong follower who can walk past a car and flip it into the air. I walk into one and I can't move it. I've also had the car or bus zooming across the sky, usually incoming, though once at L'Enfant Plaza a car was on fire and way way up in the sky. When it exploded it looked cool, then the parts rained down on us. I'm glad I can't be killed by a flying car part. I get hurt enough from skeletons lying on the floor. Annoying up at Clifftop Shacks as one shack has a room of them. I'd like a stick so I can poke them from a distance. I think it's just the room settling when the room or cell loads.
Did someone mention http://www.fallout3nexus.com/imageshare/image.php?id=13841