Fallout 3's style of level scaling was handled a lot better than oblvion's was. There will still be those places that are out of a players reach until they're a higher level, but there will be other places that scale up with the player to make things still a little hard at higher levels.
This is for the best. I disliked how little challenge Morrowind gave in the end (though absolutely owning people was fun), but I absolutely hated how Oblivion made everything "challenging" (sometimes you were a bit over or underleveled and equipped) and started to have nothing but the best gear around. Many here are mentioning bandits but IMO the worst were the goblins. I simply ran out of weapons when I went into a lair full of shamans and warlords so the fighting got unbelievably tedious and in the end I turned away as soon as I saw goblins walking in front of some cave. There was no motivation to explore either when I already had the best kinds of items around
I'd like if around 80% of things were hand-placed and some 20% scaled (but not strictly 1:1 relative to me)