Not that kinda gambling. But it would be a cool game in a tavern to maybe throw knives? xD make a bet with people and throw knives att a doll on the wall or something, hit the heart or forehead. The AI should provide a good opponent too, so another NPC can actually throw good too.
This is appropriate for Skyrim as well as fist-fights, hunting and log tossing. Poker and Black-Jack are appropriate for Red Dead Redemption.
Maybe there can be different games for Mages, Warriors and Thieves.