I *REALLY* hope things such as multiple mouse buttons will be able to help with those other functions.
Hey 4est, if this helps at all, I was pleasantly surprised with Splash Damage's control options in Quake Wars, where from beta onward I was able to configure my mousebutton 4 (thumb button) without the use of my logitech software.
I'm partial to left and right scroll getting mapped to numpad keys for extra mouse funtionality, which I believe I had to configure through Setpoint (logitech's mouse config software).
I usually use my thumb button as push to talk now though, be it ingame voice or ventrilo.