Well, the first order of business would be to work out the setting. Skyrim is a pretty cool setting for werewolves. After all, it was a hoard of werecreatures that wiped out the Snow Elves way back when. The only thing to bear in mind is that the resurgence of activity in this forum section is due to Skyrim being announced. Which means a lot of Skyrim settings. It's a matter of individual choice I suppose. I like the Skyrim setting, but there is a whole range of provinces to choose from. Maybe start in Bruma, then make the transition across the border to Skyrim?
Next, do you wish for your story to begin pre or post transformation? If pre, you could detail your character's infection and gradual transformation into the beast. If post, you could slowly reveal the fact to the reader. For example, explaining straight off the bat that she is a werewolf is slightly stale. Having her hired to track down a beast that had been terrorising a Nord village in the mountains, then having a shock twist that she actually
is the monster would be a lot more interesting. Also, would she have control over her alternate form or not? If no, does she know about her change? Does she black out before, and wake up after with no recollection? If she does have control, is she scamming the villagers by pillaging, then faking the beasts death at her hand in order to claim the reward?
Next, would there be an overarching plotline that you would be adhering to, or would it be a matter of ad-hoc writing as the fancy takes you? I would recommend setting out a loose plot in your head for the direction you wish the story to take, and how it's going to get there. Doesn't have to be a rigid and comprehensive plot, but rather a few well spaced mental bullet points that give you a general direction and framework. I've done the same for my Dres story
Varis' Venture, with a planned beginning, middle and end (well. 'Ish' on the planned end, that's up in the air). I think it leads to a far more coherent narrative anyway.
One last thing. 1st or 3rd person narrative? Is the story told by the character herself, or a narrator? So, "she opened the chest and searched for her sword", or "I opened the chest and searched for my sword"? It's best to pick one then stick with it, because mixing and matching tends to give off an unprofessional tone. Hope that helps.