I am truly confused on what is causing my current issue. Everything was working perfectly, I turned Oblivion off to go do some stuff, and when I come back my save started crashing all the time. The save became unplayable but I had a save that was just a bit back, so I loaded it up. Shortly this one started crashing as well. Since the crashes seem to be related to anything I decided to start with some of the sleep related crashes. I disabled half my mods and selectively enabled them until I found that Reneers Guard Overhaul was causing some of the sleep crashes, but once disabled only increases the frequency of some cell load crashes. I am utterly stumped. I run Bash, BOSS, TES4Edit, OBSE, Pluggy and OBMM. Also I am running a higher end computer (certainly not the one posted in my sig, but im too lazy to update it)

Oblivion.esm
Cobl Main.esm
Enhanced Daedric Invasion.esm
CyrodiilUpgradeResourcePack.esm
Armamentarium.esm
Artifacts.esm
CURP_Controller.esm
CM Partners.esm
Toaster Says Share v3.esm
CustomSpellIcons.esm
HorseCombatMaster.esm
Unofficial Oblivion Patch.esp
DLCShiveringIsles.esp
Unofficial Shivering Isles Patch.esp
PowerAttack Voicemod - The Shivering Isles.esp
Ayleid Loot EXtension.esp
Book Jackets Oblivion.esp
CT-Com's Torch Compendium.esp
P1DseeYouSleep.esp
Portable Campsite - Quickstart.esp
P1DseeYouSleep - Portable Campsite - Quickstart.esp
Reznod_Mannequin.esp
sr_super_hotkeys.esp
DLCHorseArmor.esp
DLCHorseArmor - Unofficial Patch.esp
DLCOrrery.esp
DLCOrrery - Unofficial Patch.esp
DLCVileLair.esp
DLCVileLair - Unofficial Patch.esp
P1DseeYouSleep - DLCVileLair.esp
DLCMehrunesRazor.esp
DLCMehrunesRazor - Unofficial Patch.esp
DLCSpellTomes.esp
DLCSpellTomes - Unofficial Patch.esp
AyleidFiringa.esp
AyleidMeteorIronWeaponsBASE.esp
Armory of the Silver Dragon.esp
ACCCGR SI.esp
Dread Knight Armor.esp
Hemingweys NPC Capes.esp
JG Elven.esp
MC_Staff_Pack.esp
PTArtifacts.esp
tda_Armoury Beta v1_2.esp
TT-EquipableBeards.esp
Vvardenfell_Imports.esp
XSPipeMod.esp
LichGear.esp
XiaNewAmuletsV1.esp
The Last Queen Of The Ayleids.esp
DLCThievesDen.esp
DLCThievesDen - Unofficial Patch.esp
DLCThievesDen - Unofficial Patch - SSSB.esp
Slof's Oblivion Robe Trader.esp
Cobl Glue.esp
Cobl Si.esp
Cobl Tweaks.esp
ArmamentariumLL.esp
ArmamentariumLLVendors.esp
ArmamentariumLLMagic.esp
ArmamentariumArtifacts.esp
KnightlyArmory.esp
300_Artifacts.esp
AranMathi.esp
Artifacts.esp
Artifacts - ArmaCompleteAddon.esp
BHC_Expanded.esp
Cannibalism.esp
Hammerfell.esp
ImpeREAL City Unique Districts - All the Districts - Merged.esp
Jagnot- Imperial City Library V1.3.esp
LostSwordOfTheAylied.esp
LostSwordOfTheAylied - OBSE Add-On.esp
Septim Mansion.esp
The Ayleid Steps.esp
TheElderCouncil.esp
DLCBattlehornCastle.esp
DLCBattlehornCastle - Unofficial Patch.esp
DLCFrostcrag.esp
FrostcragRebornCobl.esp
Knights.esp
Knights - Unofficial Patch.esp
The Lost Spires.esp
Lost Paladins of the Divines.esp
Origin of the Mages Guild.esp
MannimarcoComplete.esp
MannimarcoRevisited.esp
Enhanced Daedric Invasion.esp
Blackmarsh.esp
Valenwood.esp
Summerset.esp
ElsweyrAnequina.esp
Valenwood_Anequina_Patch.esp
HeartOftheDead.esp
AutoBookPlacer.esp
kikaibookbelts-tail.esp
Kyoma's Journal Mod.esp
Quest Award Leveller.esp
Quest Award Leveller - Vile Lair.esp
Quest Award Leveller - Mehrunes Razor.esp
Quest Award Leveller - Knights of the Nine.esp
Alternative Start by Robert Evrae.esp
DeathKightSpells v1_3.esp
SetEssentialActors.esp
Telekinetic Mastery.esp
unnatural_aura_by_trollf.esp
SupremeMagicka.esp
SM_ShiveringIsles.esp
SM_DLCSpellTome.esp
SM_EnchantStaff.esp
SM_VanillaSpells.esp
MidasSpells.esp
Syc_AtHomeAlchemy.esp
RshAlchemy.esp
RshAlchemyRecipes.esp
RenGuardOverhaul.esp
Deadly Reflex 5 - Timed Block with no damage or durability changes.esp
DeadlyReflex 5 - Combat Moves.esp
SM_DeadlyReflex.esp
Legendary Abilities-Shield MOJ.esp
Grandmaster of Alchemy.esp
CM Partners.esp
CM Partners More NPCs NE.esp
Companion Postal Service.esp
bgBalancingEVCore.esp
bgMagicEV.esp
bgMagicEVStartspells.esp
bgMagicEVAddEnVar.esp
bgMagicPotionNumberSoulGemValue.esp
bgBalancingEVOptionalMoreEyes.esp
bgBalancingEVOptionalNPCDiversity, Vanilla.esp
bgBalancingEVLAMEAddition.esp
bgBalancingEVLAMEGlue.esp
bgBalancingEVOptionalNPCDiversityLAME.esp
bgIntegrationEV.esp
bgMagicEVShader.esp
bgMagicShaderLifeDetect.esp
bgMagicLightningbolt.esp
Hemingweys Capes.esp
PT-AyleidSanctum-WithAltars.esp
V for vendetta.esp
Lich.esp
ParpsAyleidGuidebook 1.0.esp
Zombie Race UndeadFaction.esp
TEC_4ERA_Dialog_Filter.esp
CmHenry.esp
AT Prison.esp
Streamline 3.1.esp
Bashed Patch, 0.esp
MergedPatch.esp

The easiets explanation would be that you changed somethig else in your Windows install (added program. removed program. updated files, etc). Other than that, if you did not change or update any mods, have you tried starting a new game with the same mods installed and see if you get the same problem? How many game hours do you have on the save game that is crashing? How big is the save file?

What is the MergedPatch.esp that is loading last?

I checked and new save games are fine. The game is only about thirty hours. The mergedpatch is a tes4edit merge patch. I tried to delete the .ini and let oblivion create a new one and it still crashes. Tried to put graphics on lowest (i run on ultra) but it still crashes. One thing that seems to ALWAYS cause crashes on the game is sleeping. I use "see you sleep" so my character lies down I go through the sleep menu and when my character stands up the game crashes. I tried disabling "See you sleep" but the same thing happens.

Sorry for double post, but it appears that waiting also seems to force the CTD to occur.

Possibly something in the save? If you have save going back a bit, backtrack until you find where it went bad. There may be utilities in Wrye Bash to check the save file maybe (I never used anything other than update NPC levels). With I could be more help.

As a 'hail mary' you MIGHT want to try rebuilding your bashed patch without any script merges (or just choose leveled lists). You figure when you sleep or wait, a script must run. So try that. And maybe OBSE issue? Did you update it recently?

Odd... Odd... Odd. The CTD's only occur when I have BOTH "See you Sleep" and Ren's guard overhaul active. That's the reason it was so hard to track down the culprit since I had two working together to cause the probelm. Now that I know which mods are causing the problem I have it all sorted out. Thanks everyone.

There's a pretty good chance you don't need this. The purpose of a mergedpatch.esp file is roughly the same as the bashed patch. Bash for Oblivion is pretty advanced and likely will take care of anything the tes4edit function will do.