No, it isn't pre-rendered. It's shot in game, Obsidian and Bethesda can make some "fluid" animation when it doesn't move around the enviromment. The biggest problem in their animations is vertical movement. Other than that they can make some good animations. And NPCs can cast shadows, also anyone can make a great lighting in a room with GECK.
If you're referring to the tv ad I believe that was in game footage. In the bottom right of the screen was a notification of what the images were. Sometimes it would say "Not in game footage" like on the sniper shot, and others it would say "In game footage from PC" or some such. The last notification I saw was in game footage so I think that was in fact in game footage and Obsidian has simply improved on the animations.
This, and the sniper shot ,in case someone thinks it's pre-rendered, was on VATS.