This may have been said in a different thread or even this one but if this "hardcoe" mode doesnt make the combat more realistic (shooting a guy with 20 rounds of the LMG, like in the trailer, and he doesnt die until the NCR storm in which i consider "not realistic") then i will never play on harcore.
"Over 2000 Talk-to-able characters that can be killed and stay dead except one" does anyone know who this one lucky basterd is?
hardcoe mode does not affect weapon damage, it′s still the stats and numbers thing it was in Falout 3 (tho to some degree enemies are suposingly less bullet spunges then they where in Fallout 3)
as for the none killable, my theory is that it′s the big guy who runs Vegas, there have been hints
Spoiler that he is a super computer
and thus naturally ya can′t kill by blasting him with ya gun.