I do not want to be able to join every guild on one playthrough.
Once you get so far in a guild,you can't join others,within reason.
The guilds should allow you to do 1 or 2 quests for them,then from there you decide which line/route you take.
I'm actually wondering if there are more guilds now,because of the civil war,guilds could have split so there is a version on each side,so to speak.
I'm also wondering whether any of the guilds plays a part in the main quest.
I wouldn't be surprised if the dark brotherhood is involved some how. ( in the main quest )
In OXM UK it said bethesda seemed to be iching to mention the guilds ( factions ),but wants to save that for later.
To me guilds sound like they are going to be much,much better this time.
Guess we'll see soon enough