I have some minor problems with the audio in Daggerfall, the music, to be more specific. I don't know how to explain it, but I'll try nonetheless. Sometimes when the music is playing, there's this beeping sound that just pops in and won't go away. At other times some sort of loud rasping sound kicks in for a short amount of time, nearly giving me a hearth attack. I did not experience that much trouble with the other sounds of the game, although that's because I turn them off. The only thing I noticed when turning them on was the horse sound going even after I had just dismounted the horse.
On my brother's computer there is a major issue with the sounds. It just appeared, suddenly. The problem is, that there is a weird echoing. I noticed when it played the intro, I could hear some sort of deeper version of the emperor's voice in the background. It's slightly noticable during gamplay, as well. I played the game on that computer before, and nothing like this has ever happened.