Okay, I don't ask for help often, so frustrated. I can't for the life of me get my list of mods to work. Always CTD just as its about to get into the game. This is my list:

(Any help appreciated spend so many hours trying to figure it out =( )

Oblivion.esm
Oscuro's_Oblivion_Overhaul.esm
Mart's Monster Mod.esm
CM Partners.esm
UnnecessaryViolence.esm
HorseCombatMaster.esm
DLCShiveringIsles.esp
Natural_Weather_by_Max_Tael.esp
Natural_Habitat_by_Max_Tael.esp
All Natural - Real Lights.esp
Natural_Water_by_Max_Tael.esp
Symphony of Violence.esp
Thieves Arsenal.esp
Oscuro's_Oblivion_Overhaul.esp
Mart's Monster Mod.esp
Mart's Monster Mod for OOO.esp
OOO-WaterFish.esp
Knights.esp
The Lost Spires.esp
Natural_Vegetation_by_Max_Tael.esp
Harvest [Flora].esp
Harvest [Flora] - Shivering Isles.esp
Leviathan Soulgems.esp
Alternative Start by Robert Evrae.esp
SupremeMagicka.esp
SM_ShiveringIsles.esp
SM_OOO.esp
SM_MMM.esp
SM_EnchantStaff.esp
SM_Scrolls.esp
SM_SigilStone.esp
MidasSpells.esp
attack and hide medium v2.0.esp
AFLevelMod.esp
CM Partners.esp
CM Partners NPC.esp
CM Partners More NPCs.esp
UnnecessaryViolence.esp
Bashed Patch, 0.esp
Deadly Reflex - Timed Block + Higher Damage.esp
Mounted_Spellcasting Deadly Reflex Compatible.esp
DeadlyReflex - Combat Moves.esp

Fairly short list so we should be able to fix it quickly.

1. ATM no mounted spellcasting apart from the flea's original mod from 2007 is compatible with deadly reflex. believe me, I am horse fan and DR fan, so I regret to say get rid of Mounted_Spellcasting Deadly Reflex Compatible.esp
2. I am not sure but All Natural - Real Lights.esp might require All Natural esm file to be present and active, so try without it, if necessary start new game without it. I thik this is the reason for your CTDs. In general I'd recommend All Natural 0.9.9.5 over Natural Weather as it is new generation mod with better script, graphics etc.
3. Attack and hide has 2.1 versions with more bug fixes (nothing to do with your CTDs but thought you might want to know.)
4. Leviathan Soulgems.esp is integrated in OOO so the stand-alone esp is redundant
5. Midas Spells has OOO patch, I recommend you get it.
6. Unofficial patches. I see you've chosen not to use them. Big mistake. They are all carefully designed mods fixing thousands of discrepancies, conflicts and omissions of Bethesda developers. Besides Knights is sure to clash with MOU overhaul (i.e. MMM+OOO) you are trying to make work without the UOMP patch
7. MMM has dozens of nice modules that will make your game richer and more fun. there is a patch for Knights as well, get it.
8. Make sure you've got latest versions of all mods you use.
9. You'd better remove OOO-WaterFish.esp and use MMM Diverse Waterlife.esp - richer, better.
Good luck.

Thank you, did everything here but its still not working.

Then, how about my favorite method of hunting down the culprit?
Untick Bashed patch, try to load. If not - untick 5 mods, try, and so on, until you find out whichmod causes it.

incidentally, did you try to delete your Oblivion.ini and start the game so it generates a new one?