I'm not sure if this was mentioned before but i'll say it any way. When you start Fallout New Vegas, alt tab out of the game, then Ctrl Alt Del and go to task manager, processes and right click the FalloutNV.exe and set priority to low. This also works in other games as well, though I'm not sure if it works for all, and also do not exit the game after doing this, or you will have to do this process again, also you have to do this every time you start up the game. also for 64 bit users such as myself, use this http://www.newvegasnexus.com/downloads/file.php?id=35262 and do the low priority fix as well for maximum smoothness