I've heard of items not showing, but not crashes. Could you do a bit of debugging, and see if you still get the crashes after placing the items in a nearby container that wasn't the Sorter? (The grinder would be best.) Make sure to dump everything that had been in the Sorter. I'm going to go out on a (fairly long) limb here and guess that it's the number of individual items (100 different ingredients) rather than the total number of items (10 Oranges + 10 Apples).
Well if it helps, when I encountered the problem I was using XJDHDR's "Basemant for Cobl" mod which is basically all the (I must say excellent and don't know how I did without them!) Cobl goodies and comprises a Cobl alchemy sorter, static alchemy equipment table, The Luggage, grinder, food cupboard and linked static dinner plate (which I use with Cobl-aware Real Hunger), water keg, as well as a few normal non-respawning containers and a bed, I bought a trashcan and put it in there as well.
I had previously stored literally thousands of samples of bonemeal in the sorter with absolutely no issue whatsoever, the problem occurred after 200+ hours of play when I had in the sorter at least one sample of every available potion, ingredient and scroll, but I'd long since used my large stockpile of bonemeal and I didn't at that point have any single item in a quantity larger than 20 - so if there is a problem it is more than likely caused by a long list of contents, rather than a short list of contents with large quantities. Interestingly, I experienced very little lag when using the sorter even when using the 'open container' option on the menu to view all contents, and apparently no items not displaying in the container (which as a hoarder I sort of expect!) when I did run into difficulties, my first warning of any problem was the inability to continue my game without a CTD after I'd sorted stuff into it.
I moved my mmm crafting supplies from a normal container in that cell (bones, pelts, ores and nuggets - I'd been saving them up with the full intention of trying out some crafting but not yet got round to doing it) to the bedroom of my Skingrad house and removed all the potions from the alchemy sorter and put them in one of the chests in the same room as the sorter (in XJDHDR's basemant) and all now appears to be OK.