They said you will be able to make friends with NPC's and some will go with you on your adventures. So yes.
To touch on that, an actual companion system hasnt been confirmed. So far, we can only assume that there is a 'follower' system similar to OB (Think Adoring Fan, etc) in which people will tag a long into battles with you. In OB however, these people were hardly interactive like FO3 and better yet FO NV.
I find it hard to believe that there wont be companions, especially seeing the way the were implemented in FO3 and then improved in FO NV. Just my thoughts. I certainly want companions.