Before the patch FPS where fine. Now, there are extreme lags (e.g. the whole sewer system or the fiends territory). FPS take a dive as soon as the mouse is moved, resulting in a stuttering experience.
Loading times increased significantly now.
Worse: The game crashes randomly after 5-15 minutes regardles of location or action. That is soooo annoying!

Weapons tend to hang now and the game ignores the key presses (e.g. hunting shotgun). Some frenzied key pressing remedies this situation (thank god I was only encountering rats...).
Rex gets stuck indoors very often (Vault 3). Leaving an area seems to solve it, until he gets stuck again (maybe that's just a quirk of his deteriorating brain...).
I hope Bethesda is not living under a rock and we will see a timely solution to this problem. NW as it is now, is not entertaining anymore.
Cheers
Chris