@roxahris: I can't offer a whole lot of support for plugins other than to suggest you isolate the problematic ones and get in touch with their authors. You might try without Construction Set Extender just for kicks - because it's new and therefore less thoroughly tested, and unlike your other plugins it modifies the editor executable, not because I have any reason to think there's a problem with it.

@everybody else: 0020 beta 2 is now available, so let's head over to a http://www.gamesas.com/index.php?/topic/1156057-beta-oblivion-script-extender-obse-v0020/.