Kvatch Rebuilt
Kvatch Aftermath
Prolly most other Kvatch rebuilding mods too.
Integration (Rebuild a a "forgotten city"* with Telvanni mushrooms, recruit the inhabitants, be appointed as the figure head, do several quests and such for "your people."
Windfall (resolve a civil war and potentially be appointed Count, in which case you do.... absolutely nothing further.)
If you mean in a Real Time Settler/ Wasteland Defense type way, no I am not aware of anything.
*Mir Corrup. The city is mentioned in several vanilla books, and a location for it is even given in the books, but it is missing from the game.