I've been using that old survival mod http://www.tesnexus.com/downloads/file.php?id=24079 for many many hours of play. I never found a newer one that I liked as much as Tyler's. It has its flaws for sure but overall I like how it works.
I did not like Vim and Vigor and I understand from the Time Manager readme that it tends to fight with VV.
One of them is: if you buy a bedroll, open it, then go off and leave it and forget where it is, then buy another one and try to open it, you'll get an error message saying "You've already opened your bedroll."
In the past I've fixed this by: (i) closing the game; (ii) deactivating Tyler's HTST in OBMMM; (iii) reopen the save and move to a new cell; (iv) save a new save and exit game; (v) reactivate HTST in OBMM; (vi) restart the save and either repurchase the Bedroll and Wellkey or additem them using the console.
I recently tried to follow this procedure and every time I get to step (vi) the load bar gets about 1/5th progressed and then just sits there. I defragged my machine last night, though I have not tried to get HTST rerunning again, I'm currently runing without it. Playing this game without a surival mod that forces me to eat, drink and sleep is just not fun.
I'm going to see if deactiving Time Manager and then reactivating HTST can get it working again, but HTST is so old, maybe there is a better option?