As the creator of Enhanced Hotkeys I of course endorse Belanos' comment

With Enhanced Hotkeys, the hotkey grid changes to a grid with the number of columns and rows you want (ex: 4x10 for 40 accessible hotkeys). You can also define up to 3 secondary "wheel" for a total of 120 hotkeys. Furthermore, you can assign several items/spells to one single hotkey and change how EH handles it by clicking on the hotkey icon. If you assign 1 spell to a hotkey, clicking on it toggles between normal and auto-cast mode. In auto-cast mode, the spell is cast, without being selected when you tap the hotkey. Similarly, if you assign 4 spells to one hotkey, you can decide whether it behaves like a cycler or a multi-cast key. If a cycler, tapping the hotkey once will select the first spell, tapping it again will select the second, etc. If multi-cast, tapping the hotkey will cast all 4 in fast sequence without changing which spell you have selected.
There are similar functionality for items too...
Improved Hotkey's I say you can even modify the keys for the secondary cycles.
You basicly have one row of 1-8 , now you can have 3 rows of 1-8 not to mention that you can change gear from 9 0 - =
http://www.tesnexus.com/downloads/file.php?id=18571
As creator of Enhanced Hotkeys, I'm not exactly neutral, but everything Improved Hotkeys does, is handled better by Enhanced Hotkeys.