I'm a PS3 player with no bugs, so there's a confirmation of few technical problems with a person playing from each platform. Why is it that some of us have games running fine when others do not?
That's sort of the way it is with PC games. In this case, there is a problem with DX9 implementation for high-end hardware on Vista or Win7 (basically, cards capable of DX10 or 11). It seems particularly bad for people with Nvidia 400 series cards. Framerates plummet whenever an NPC speaks on-screen, and are lower than they should be in general. Luckily, an old community fix from Fallout3 happened to correct the issue, and now I'm getting better framerates than I do in Fallout3.
The other game-stopper for me was the save bug. When they had Steam Cloud activated on the Steam servers, a lot of us were finding that our quicksave and autosave files were being replaced with earlier ones every time the game was launched (even if we had set Steam to not use Cloud). Several of us eventually found a way to prevent it through trial and error, and it has since been patched.
Spending my first two evenings with the game troubleshooting instead of playing spoiled my excitement a little, But now that I've been able to get into the game, I'm really enjoying it. I think I'll be spending a LOT of time in the Mojave Wasteland over the next year or two...
:fallout: