Well it is your game. And the Dev's did give you plenty of great things and "toys" to make the game exciting....
Perhaps those annoying people should just be wiped out with a little pickpocketing and C-4? That's sure to give you an exciting little fire-fight with there allies.
Why dont you try charging all three casinos on The Strip with only a 9mm pistol and 3 stimpacks?
Or taking on Black Mountain? Im sure there are some familiar faces there to remind you of FO3.... two of those you mentioned are there.