It took me ages to find a sniper rifle, which is my weapon of choice. Once I found one I was very pleased with it!
Fortunately, one of the fundamental changes with FONV is that combat is just as effective without VATS as it is with it. You needed mods to do that in FO3. Even so, sniping is a fun way to go.
I was using a scoped laser rifle for awhile, but switched to a Gauss Rifle. It doesn't have the ammo options my anti-material or sniper rifles do, but I get free ammo for it from a questline I did. I don't ever have to worry about ammo which is handy if you're working on building up the damage boost perks.