From grenades to the missile launcher, explosive weapons are simply not worth their cost and weight. In -every- situation using traditional bullets or energy weapons will result in higher dps. Kind of stupid that a .50 caliber round does twice as much as missile to the face every time. Also, explosives destroy loot. The only explosive worth using are mines, and those are so situational that you can basically ignore them.
I find pulse grendades still usefull... However im not sure about Explosives like nade launchers and stuff... My skill is only like level 20 and they do crap for dmg, however im leve 22 right now.. There are alot of Perks for explosives.. Do you have them ? How high is your explosive skill ?