I am trying to do every quest in the game,but i know that if you side with one faction you can't do some quest for example, if your with Mr.house you can't do all of caesar's legion ones.At the moment i'm doing i have saved a profile for.Mr.house,NCR,Yes man.When i get around to doing caesar's quest would i be able to get along with other groups such as The Great Khans,Powder Gangers,Fiends so i can just do there quests as well or would i have to do another save.Also i was just wondering as well i know in the beginning of the game you have to defend Goodsprings from the Powder gangers i belive i could be wrong i don't really remember.If i did help the Goodsprings could i go back and kill everyone at Goodsprings to regain reputation with the powder gangers? If anyone could help me with any part of this question that wold be great thank you

Lots of questions in there, will try to answer what I can.
If you work for Caesar, the primary groups you will be denied quests for are House and the NCR. The Legion will eventually want you to wipe out the Brotherhood of Steel, too, but seem to ignore most other factions as far as their questline is concerned (you can get the Boomers to help them too). The Legion is basically hostile to everyone except the Great Khans when the player comes into the picture. You can do quests for almost everyone else besides the NCR and Mr House, although causing the Great Khans to abandon the alliance with Caesar may cause problems, likewise killing Vulpes at any point will deny you a questline or two.

As far as Goodsprings goes, you have to make the choice when you pick up the quest if you are helping Ringo or Joe Cobb. Once you finish the first step of the quest for one side, you are pretty much locked out of helping the other side (Cobb wants you to kill Ringo first). Going back and just killing people will do nothing but get the town angry at you and deny you several vendors, there are no NPCs you can kill to farm positive rep with a faction, NPCs on factions only cause you to lose rep with their specific group when you kill them. The quests are considered mutually exclusive, much like the quests for Nelson/Forlorn Hope.