What I want most of all from the PC version of Skyrim is the ability of different mods to alter the same object without the use of a Bashed Patch. For instance, a modded PC could have inventory from Mod A, a script from Mod B and additional spells from Mod C. A chest could have items from many different mods in it, instead of being overwritten by the last one. You get the idea. For mods that alter the same part of an object, like an NPC's strength, then the last one would have to win.

It certainly would be nice if the engine could discriminate by modified attribute rather than modified item. It would result in a lot less headaches.

What I'm hoping for is a decent scripting architecture. That way I don't have to rely on something like MWSE/OBSE for the super-crunchy mods.