There's one quest in particular that either a time bomb, C4 with a remote detonator, or a trail of frag mines is handy for.
To set off the gas in Vault22 for Keeley
I use a long fuse dynamite for that and run for it works every time.
Do tell, what is that quest, and what is the Shady Sands Shuffle. I did figure out it would be useful at one point in Vault 22.
Its the quest where you have to set off gas in Vault 22. I personally use a long fuse dynamite since I dont even waste time with building the time bombs. Its like the powder charge I dont even mess with them I just sell the junk. The Shady Sands Shuffle atleast I see it refered to it is pickpocking someone and putting a live frag grenade, dynamite, C-4, Timebomb, or any explosive that will blow them up. It is fun to do but sneek skill needs to be high to have a good success rate. Otherwise you get caught a fair amount of time.
Only thing I found real useful is the bottlecap mine but I dont know if it will still blow the leg off a deathclaw with one hit like in FO3 or not and I am not going to experiment to find out. last time I went up against one I ended up getting gang [censored] by 6 of them at once out of no wheres.