I think he's just talking about regular marked/unmarked quests. Not a dedicated content update. Something that uses existing characters/locations but gives something new/random to do with them.
I think this.
It would be nice, certainly to see the places and people you've met evolving and getting on with their lives, or deaths..
Allthough it would put off that battle for the dam somewhat!
"Allthight guys, hold off on the battle, that one courier who seems harder than the rest of us has wandered off to this casino in the middle of the desert somewjhere!"